Fourth generation · W220 · 2000–2006
2006Mercedes-Benz S-Class
A lighter, sleeker S-Class with Airmatic air suspension, Distronic radar cruise, and the Pre-Safe pre-collision system (2002). Topped by the bi-turbo V12 S 600 and AMG S 65. US model years 2000–2006.
Photo: “2006 Mercedes S320 CDi Auto” by Calreyn88 / Wikimedia Commons, licensed under CC BY-SA 4.0. Cropped to 16:9.
Start here
What do you need to know?
This page covers the whole 2006 Mercedes-Benz S-Class model year. Choose your task first; exact trims and engines are separated where the factory offered different versions.
Complete, source-verified lineup
Find your exact 2006 S-Class
Start with a family, body style, or engine. Every card opens the facts and maintenance information for that factory version.
Verified complete for the U.S.-marketHow this lineup was verified
We checked this U.S.-market lineup against period sources for factory sedan, coupe, cabriolet, drivetrain, and powertrain roster represented by the cited exact-year or factory-archive evidence. Every version shown below has its own detail page.
Verified 2026-09-01 from Mercedes-Benz USA — model year 2006 S-Class sales presentation guide.
Mercedes-Benz S 350 Automatic
- Body
- Four-door rear-wheel drive luxury sedan
- Engine
- 3.7-liter M112 V6
- Gearbox
- 5-speed automatic
- Built
- Regular production
Mercedes-Benz S 430 Automatic
- Body
- Four-door rear-wheel drive luxury sedan
- Engine
- 4.3-liter M113 V8
- Gearbox
- 7-speed automatic
- Built
- Regular production
Mercedes-Benz S 430 4MATIC Automatic
- Body
- Four-door 4MATIC all-wheel drive luxury sedan
- Engine
- 4.3-liter M113 V8
- Gearbox
- 5-speed automatic
- Built
- Regular production
Mercedes-Benz S 500 Automatic
- Body
- Four-door rear-wheel drive luxury sedan
- Engine
- 5.0-liter M113 V8
- Gearbox
- 7-speed automatic
- Built
- Regular production
Mercedes-Benz S 500 4MATIC Automatic
- Body
- Four-door 4MATIC all-wheel drive luxury sedan
- Engine
- 5.0-liter M113 V8
- Gearbox
- 5-speed automatic
- Built
- Regular production
Mercedes-Benz S 55 AMG Automatic
- Body
- Four-door rear-wheel drive luxury sedan
- Engine
- 5.4-liter supercharged AMG V8
- Gearbox
- 5-speed automatic
- Built
- Regular production
Mercedes-Benz S 600 Automatic
- Body
- Four-door rear-wheel drive luxury sedan
- Engine
- 5.5-liter twin-turbo M275 V12
- Gearbox
- 5-speed automatic
- Built
- Regular production
Mercedes-Benz S 65 AMG Automatic
- Body
- Four-door rear-wheel drive luxury sedan
- Engine
- 6.0-liter twin-turbo AMG V12
- Gearbox
- 5-speed automatic
- Built
- Regular production
No factory configuration matches those filters.
The 2006 model year
Overview
The 2006 U.S. S-Class remained the W220 and closed the generation with eight configurations. Mercedes-Benz USA's exact-year sales guide lists the standard-wheelbase S 350; rear- and 4MATIC S 430 and S 500 sedans; S 55 AMG; S 600; and S 65 AMG. The W221 shown globally in 2005 is assigned to U.S. model year 2007 in this catalog.
Specifications
- Engines
- 3.7-liter M112 V6
- 4.3-liter M113 V8
- 5.0-liter M113 V8
- 5.4-liter supercharged AMG V8
- 5.5-liter twin-turbo M275 V12
- 6.0-liter twin-turbo AMG V12
- Transmissions
- 5-speed automatic, 7-speed automatic
- Body styles
- Four-door rear-wheel drive luxury sedan, Four-door 4MATIC all-wheel drive luxury sedan
Year over year
What changed
- The 3.7-liter V6 S 350 joined as a standard-wheelbase U.S. entry model.
- The seven established V8, 4MATIC, AMG, and V12 configurations carried through the final U.S. W220 model year.
Worth knowing
Notable
- The factory guide calls this the current W220-series S-Class, making a 2006 W221 generation label or hero image incorrect for this U.S.-model-year page.
Living with it
Reliability & ownership notes
- Inspect the individual car's Airmatic or optional Active Body Control system, electronics, corrosion condition, and documented service history; generation reputation is not proof of a fault on every car.
- Match filters, ignition parts, fluids, transmission service parts, and suspension components to the exact engine, drivetrain, chassis number, and build date before ordering.
Maintenance & service parts
Keep your 2006 S-Class on the road
Start with the service interval, then match the engine or exact version you own. Order links appear only when a catalog-backed part number is available, and every listing still needs a fitment check.
Service desk
What this car needs & when
Use this as a service-planning checklist for 2006 Mercedes-Benz S-Class. Start with the interval, confirm which engine or configuration you have, then use an exact ordering reference when one is verified.
- Service topics
- 9
- Factory intervals
- 9
- Fitment-scoped
- 9
- Exact references
- 1
Before orderingIdentify your engine, options and build date.Part numbers and sizes can change within one model year. Shopping links appear only for catalog-backed references; still verify the listing against your vehicle before ordering.
Engine oil and filter
Sourced interval available
Source: Mercedes-Benz — 2006 S 600 (W220/M275) MBMS schedule, preserved by Operation CHARM · Service A/B schedules — oil/filter at both services; first A at 10,000 miles/one year · checked
Combination/dust filter
Sourced interval available
Source: Mercedes-Benz — 2006 S 600 (W220/M275) MBMS schedule, preserved by Operation CHARM · Service B schedule — replace combination/dust filter · checked
Automatic-transmission oil and filter
Sourced interval available
Source: Mercedes-Benz — 2006 S 600 (W220/M275) MBMS schedule, preserved by Operation CHARM · Supplemental Service Items — Once at 40,000 miles · checked
Brake fluid
Sourced interval available
Source: Mercedes-Benz — 2006 S 600 (W220/M275) MBMS schedule, preserved by Operation CHARM · Supplemental Service Items — Every 2 Years · checked
Poly-V-belt tensioning device
Sourced interval available
Source: Mercedes-Benz — 2006 S 600 (W220/M275) MBMS schedule, preserved by Operation CHARM · Supplemental Service Items — Every 40,000 miles or 4 Years · checked
Engine air-filter element
Exact reference available
Source: Mercedes-Benz — 2006 S 600 (W220/M275) MBMS schedule, preserved by Operation CHARM · Supplemental Service Items — Every 60,000 miles or 4 Years · checked
S 350 — 3.7-liter M112 V6
K&N 33-2181
Source: K&N Engineering — 2017 European Automotive Catalog, S-Class application tables (archived copy) · W220 S-Class table — S 350, 2006 — 33-2181 (two required) · checked
Verified ordering references
- Service replacementK&N 33-2181
Qty. 2 · Reusable engine air-filter element · catalog-listed
K&N lists two elements for this application; confirm VIN and build date before ordering.
Catalog: K&N Engineering — 2017 European Automotive Catalog, S-Class application tables (archived copy) · W220 S-Class table — S 350, 2006 — 33-2181 (two required) · checked
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S 430 — 4.3-liter M113 V8
K&N 33-2181
Source: K&N Engineering — 2017 European Automotive Catalog, S-Class application tables (archived copy) · W220 S-Class table — S 430, 2006 — 33-2181 (two required) · checked
Verified ordering references
- Service replacementK&N 33-2181
Qty. 2 · Reusable engine air-filter element · catalog-listed
K&N lists two elements for this application; confirm VIN and build date before ordering.
Catalog: K&N Engineering — 2017 European Automotive Catalog, S-Class application tables (archived copy) · W220 S-Class table — S 430, 2006 — 33-2181 (two required) · checked
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S 430 4MATIC — 4.3-liter M113 V8
K&N 33-2181
Source: K&N Engineering — 2017 European Automotive Catalog, S-Class application tables (archived copy) · W220 S-Class table — S 430 4MATIC, 2006 — 33-2181 (two required) · checked
Verified ordering references
- Service replacementK&N 33-2181
Qty. 2 · Reusable engine air-filter element · catalog-listed
K&N lists two elements for this application; confirm VIN and build date before ordering.
Catalog: K&N Engineering — 2017 European Automotive Catalog, S-Class application tables (archived copy) · W220 S-Class table — S 430 4MATIC, 2006 — 33-2181 (two required) · checked
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S 500 — 5.0-liter M113 V8
K&N 33-2181
Source: K&N Engineering — 2017 European Automotive Catalog, S-Class application tables (archived copy) · W220 S-Class table — S 500, 2006 — 33-2181 (two required) · checked
Verified ordering references
- Service replacementK&N 33-2181
Qty. 2 · Reusable engine air-filter element · catalog-listed
K&N lists two elements for this application; confirm VIN and build date before ordering.
Catalog: K&N Engineering — 2017 European Automotive Catalog, S-Class application tables (archived copy) · W220 S-Class table — S 500, 2006 — 33-2181 (two required) · checked
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S 500 4MATIC — 5.0-liter M113 V8
K&N 33-2181
Source: K&N Engineering — 2017 European Automotive Catalog, S-Class application tables (archived copy) · W220 S-Class table — S 500 4MATIC, 2006 — 33-2181 (two required) · checked
Verified ordering references
- Service replacementK&N 33-2181
Qty. 2 · Reusable engine air-filter element · catalog-listed
K&N lists two elements for this application; confirm VIN and build date before ordering.
Catalog: K&N Engineering — 2017 European Automotive Catalog, S-Class application tables (archived copy) · W220 S-Class table — S 500 4MATIC, 2006 — 33-2181 (two required) · checked
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S 55 AMG — 5.4-liter supercharged AMG V8
K&N 33-2181
Source: K&N Engineering — 2017 European Automotive Catalog, S-Class application tables (archived copy) · W220 S-Class table — S 55 AMG, 2006 — 33-2181 (two required) · checked
Verified ordering references
- Service replacementK&N 33-2181
Qty. 2 · Reusable engine air-filter element · catalog-listed
K&N lists two elements for this application; confirm VIN and build date before ordering.
Catalog: K&N Engineering — 2017 European Automotive Catalog, S-Class application tables (archived copy) · W220 S-Class table — S 55 AMG, 2006 — 33-2181 (two required) · checked
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S 600 — 5.5-liter twin-turbo M275 V12
K&N 33-2412
Source: K&N Engineering — 2017 European Automotive Catalog, S-Class application tables (archived copy) · W220 S-Class table — S 600, 2006 — 33-2412 · checked
Verified ordering references
- Service replacementK&N 33-2412
Qty. 1 · Reusable engine air-filter element · catalog-listed
K&N lists one element for this application; confirm VIN and build date before ordering.
Catalog: K&N Engineering — 2017 European Automotive Catalog, S-Class application tables (archived copy) · W220 S-Class table — S 600, 2006 — 33-2412 · checked
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S 65 AMG — 6.0-liter twin-turbo AMG V12
K&N 33-2412
Source: K&N Engineering — 2017 European Automotive Catalog, S-Class application tables (archived copy) · W220 S-Class table — S 65 AMG, 2006 — 33-2412 · checked
Verified ordering references
- Service replacementK&N 33-2412
Qty. 1 · Reusable engine air-filter element · catalog-listed
K&N lists one element for this application; confirm VIN and build date before ordering.
Catalog: K&N Engineering — 2017 European Automotive Catalog, S-Class application tables (archived copy) · W220 S-Class table — S 65 AMG, 2006 — 33-2412 · checked
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Fuel filter
Sourced interval available
Source: Mercedes-Benz — 2006 S 600 (W220/M275) MBMS schedule, preserved by Operation CHARM · Supplemental Service Items — Every 60,000 miles or 5 Years · checked
Spark plugs
Sourced interval available
Source: Mercedes-Benz — 2006 S 600 (W220/M275) MBMS schedule, preserved by Operation CHARM · Supplemental Service Items — Every 60,000 miles or 5 Years · checked
Low-temperature-circuit coolant
Sourced interval available
Source: Mercedes-Benz — 2006 S 600 (W220/M275) MBMS schedule, preserved by Operation CHARM · Supplemental Service Items — Every 150,000 miles or 15 Years · checked
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