Fifth generation · W221 · 2007–2013
2007Mercedes-Benz S-Class
Brought Night View Assist and the first S-Class hybrid (S 400 Hybrid, 2010). The two-door flagship continued as the separate CL-Class (C216) during this era.
Photo: “2007 Mercedes-Benz S 500 L (V 221) sedan (2012-12-10)” by FotoSleuth / Wikimedia Commons, licensed under CC BY 2.0. Cropped to 16:9.
Start here
What do you need to know?
This page covers the whole 2007 Mercedes-Benz S-Class model year. Choose your task first; exact trims and engines are separated where the factory offered different versions.
Complete, source-verified lineup
Find your exact 2007 S-Class
Start with a family, body style, or engine. Every card opens the facts and maintenance information for that factory version.
Verified complete for the U.S.-marketHow this lineup was verified
We checked this U.S.-market lineup against period sources for factory sedan, coupe, cabriolet, drivetrain, and powertrain roster represented by the cited exact-year or factory-archive evidence. Every version shown below has its own detail page.
Verified 2026-09-01 from Mercedes-Benz Public Archive — 221-series S-Class model history.
Mercedes-Benz S 550 Automatic
- Body
- Four-door rear-wheel drive luxury sedan
- Engine
- 5.5-liter V8
- Gearbox
- 7-speed automatic
- Built
- Regular production
Mercedes-Benz S 550 4MATIC Automatic
- Body
- Four-door 4MATIC all-wheel drive luxury sedan
- Engine
- 5.5-liter V8
- Gearbox
- 7-speed automatic
- Built
- Regular production
Mercedes-Benz S 600 Automatic
- Body
- Four-door rear-wheel drive luxury sedan
- Engine
- 5.5-liter twin-turbo V12
- Gearbox
- 5-speed automatic
- Built
- Regular production
Mercedes-Benz S 65 AMG Automatic
- Body
- Four-door rear-wheel drive luxury sedan
- Engine
- 6.0-liter twin-turbo AMG V12
- Gearbox
- 5-speed automatic
- Built
- Regular production
No factory configuration matches those filters.
The 2007 model year
Overview
The W221 became the U.S. S-Class for 2007. Mercedes-Benz's factory archive identifies rear- and all-wheel-drive S 550 sedans plus the rear-drive S 600 and S 65 AMG, keeping drivetrain and V8/V12 service boundaries separate.
Specifications
- Engines
- 5.5-liter V8
- 5.5-liter twin-turbo V12
- 6.0-liter twin-turbo AMG V12
- Transmissions
- 7-speed automatic, 5-speed automatic
- Body styles
- Four-door rear-wheel drive luxury sedan, Four-door 4MATIC all-wheel drive luxury sedan
Year over year
What changed
- An all-new W221 body replaced the final U.S. W220 range.
- The S 550 was offered with rear-wheel drive or 4MATIC; the two V12 flagships remained rear-wheel drive.
Worth knowing
Notable
- This page follows the U.S. 2007 model-year boundary rather than the W221's earlier global presentation date.
Living with it
Reliability & ownership notes
- Inspect Airmatic or Active Body Control operation, electronics, cooling-system condition, and documented service history on the individual car; a generation-level reputation is not evidence that every example has a fault.
- Match filters, fluids, ignition or diesel-service parts, brakes, and transmission service items to the exact engine, drivetrain, build date, and VIN before ordering.
Maintenance & service parts
Keep your 2007 S-Class on the road
Start with the service interval, then match the engine or exact version you own. Order links appear only when a catalog-backed part number is available, and every listing still needs a fitment check.
Service desk
What this car needs & when
Use this as a service-planning checklist for 2007 Mercedes-Benz S-Class. Start with the interval, confirm which engine or configuration you have, then use an exact ordering reference when one is verified.
- Service topics
- 7
- Factory intervals
- 7
- Fitment-scoped
- 7
- Exact references
- 1
Before orderingIdentify your engine, options and build date.Part numbers and sizes can change within one model year. Shopping links appear only for catalog-backed references; still verify the listing against your vehicle before ordering.
Engine oil and filter
Sourced interval available
Source: Mercedes-Benz — 2007 S 550 (W221/M273) service schedule, preserved by Operation CHARM · US Service 3 — Every 13,000 Miles or 1 Year · checked
Combination cabin filter
Sourced interval available
Source: Mercedes-Benz — 2007 S 550 (W221/M273) service schedule, preserved by Operation CHARM · US Service 5 — Every 26,000 Miles or 2 Years · checked
Brake fluid
Sourced interval available
Source: Mercedes-Benz — 2007 S 550 (W221/M273) service schedule, preserved by Operation CHARM · US Service 4 — Every 2 Years · checked
Engine air-cleaner insert
Exact reference available
Source: Mercedes-Benz — 2007 S 550 (W221/M273) service schedule, preserved by Operation CHARM · US Service 8 — Every 52,000 Miles or 4 Years · checked
S 550 — 5.5-liter V8
K&N 33-2181
Source: K&N Engineering — 2017 European Automotive Catalog, S-Class application tables (archived copy) · W221 S-Class table — S 550, 2007 — 33-2181 (two required) · checked
Verified ordering references
- Service replacementK&N 33-2181
Qty. 2 · Reusable engine air-filter element · catalog-listed
K&N lists two elements for this application; confirm VIN and build date before ordering.
Catalog: K&N Engineering — 2017 European Automotive Catalog, S-Class application tables (archived copy) · W221 S-Class table — S 550, 2007 — 33-2181 (two required) · checked
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S 550 4MATIC — 5.5-liter V8
K&N 33-2181
Source: K&N Engineering — 2017 European Automotive Catalog, S-Class application tables (archived copy) · W221 S-Class table — S 550 4MATIC, 2007 — 33-2181 (two required) · checked
Verified ordering references
- Service replacementK&N 33-2181
Qty. 2 · Reusable engine air-filter element · catalog-listed
K&N lists two elements for this application; confirm VIN and build date before ordering.
Catalog: K&N Engineering — 2017 European Automotive Catalog, S-Class application tables (archived copy) · W221 S-Class table — S 550 4MATIC, 2007 — 33-2181 (two required) · checked
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S 600 — 5.5-liter twin-turbo V12
K&N 33-2412
Source: K&N Engineering — 2017 European Automotive Catalog, S-Class application tables (archived copy) · W221 S-Class table — S 600, 2007 — 33-2412 · checked
Verified ordering references
- Service replacementK&N 33-2412
Qty. 1 · Reusable engine air-filter element · catalog-listed
K&N lists one element for this application; confirm VIN and build date before ordering.
Catalog: K&N Engineering — 2017 European Automotive Catalog, S-Class application tables (archived copy) · W221 S-Class table — S 600, 2007 — 33-2412 · checked
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S 65 AMG — 6.0-liter twin-turbo AMG V12
K&N 33-2412
Source: K&N Engineering — 2017 European Automotive Catalog, S-Class application tables (archived copy) · W221 S-Class table — S 65 AMG, 2007 — 33-2412 · checked
Verified ordering references
- Service replacementK&N 33-2412
Qty. 1 · Reusable engine air-filter element · catalog-listed
K&N lists one element for this application; confirm VIN and build date before ordering.
Catalog: K&N Engineering — 2017 European Automotive Catalog, S-Class application tables (archived copy) · W221 S-Class table — S 65 AMG, 2007 — 33-2412 · checked
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Fuel filter
Sourced interval available
Source: Mercedes-Benz — 2007 S 550 (W221/M273) service schedule, preserved by Operation CHARM · US Service 11 — Every 143,000 Miles or 15 Years · checked
Spark plugs
Sourced interval available
Source: Mercedes-Benz — 2007 S 550 (W221/M273) service schedule, preserved by Operation CHARM · US Service 12 — Every 91,000 Miles or 5 Years · checked
Engine coolant
Sourced interval available
Source: Mercedes-Benz — 2007 S 550 (W221/M273) service schedule, preserved by Operation CHARM · US Service 13 — Every 143,000 Miles or 15 Years · checked
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Sources
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