2010 Mercedes-Benz S-Class | Car Model History

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What do you need to know?

This page covers the whole 2010 Mercedes-Benz S-Class model year. Choose your task first; exact trims and engines are separated where the factory offered different versions.

Complete, source-verified lineup

Find your exact 2010 S-Class

Start with a family, body style, or engine. Every card opens the facts and maintenance information for that factory version.

6factory configurations

Verified complete for the U.S.-marketHow this lineup was verified

We checked this U.S.-market lineup against period sources for factory sedan, coupe, cabriolet, drivetrain, and powertrain roster represented by the cited exact-year or factory-archive evidence. Every version shown below has its own detail page.

Verified 2026-09-01 from Mercedes-Benz Public Archive — 221-series S-Class model history.

Four-door rear-wheel drive luxury sedan

Mercedes-Benz S 400 HYBRID Automatic

Body: Four-door rear-wheel drive luxury sedan
Engine: 3.5-liter V6 with electric motor
Gearbox: 7-speed automatic
Built: Regular production

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Four-door rear-wheel drive luxury sedan

Mercedes-Benz S 550 Automatic

Body: Four-door rear-wheel drive luxury sedan
Engine: 5.5-liter V8
Gearbox: 7-speed automatic
Built: Regular production

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Four-door 4MATIC all-wheel drive luxury sedan

Mercedes-Benz S 550 4MATIC Automatic

Body: Four-door 4MATIC all-wheel drive luxury sedan
Engine: 5.5-liter V8
Gearbox: 7-speed automatic
Built: Regular production

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Four-door rear-wheel drive luxury sedan

Mercedes-Benz S 600 Automatic

Body: Four-door rear-wheel drive luxury sedan
Engine: 5.5-liter twin-turbo V12
Gearbox: 5-speed automatic
Built: Regular production

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Four-door rear-wheel drive luxury sedan

Mercedes-Benz S 63 AMG Automatic

Body: Four-door rear-wheel drive luxury sedan
Engine: 6.2-liter AMG V8
Gearbox: 7-speed automatic
Built: Regular production

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Four-door rear-wheel drive luxury sedan

Mercedes-Benz S 65 AMG Automatic

Body: Four-door rear-wheel drive luxury sedan
Engine: 6.0-liter twin-turbo AMG V12
Gearbox: 5-speed automatic
Built: Regular production

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The 2010 model year

Overview

For 2010, Mercedes-Benz added the rear-wheel-drive S 400 HYBRID to the U.S. W221 range. Its gasoline-electric powertrain sits alongside, rather than replacing, the S 550 pair, S 600, S 63 AMG, and S 65 AMG.

Specifications

Engines: 3.5-liter V6 with electric motor
5.5-liter V8
5.5-liter twin-turbo V12
6.2-liter AMG V8
6.0-liter twin-turbo AMG V12
Transmissions: 7-speed automatic, 5-speed automatic
Body styles: Four-door rear-wheel drive luxury sedan, Four-door 4MATIC all-wheel drive luxury sedan

Year over year

What changed

The S 400 HYBRID became the first hybrid configuration in the U.S. S-Class roster.
Six configurations now spanned hybrid, naturally aspirated V8, and twin-turbo V12 applications.

Worth knowing

Notable

The hybrid requires its own high-voltage and service-parts applicability rather than sharing the S 550 page.

Living with it

Reliability & ownership notes

Inspect Airmatic or Active Body Control operation, electronics, cooling-system condition, and documented service history on the individual car; a generation-level reputation is not evidence that every example has a fault.
Match filters, fluids, ignition or diesel-service parts, brakes, and transmission service items to the exact engine, drivetrain, build date, and VIN before ordering.

Maintenance & service parts

Keep your 2010 S-Class on the road

Start with the service interval, then match the engine or exact version you own. Order links appear only when a catalog-backed part number is available, and every listing still needs a fitment check.

Service topics: 5
Factory intervals: 5
Fitment-scoped: 5
Exact references: 1

Before orderingIdentify your engine, options and build date.Part numbers and sizes can change within one model year. Shopping links appear only for catalog-backed references; still verify the listing against your vehicle before ordering.

Engine oil and filter
Sourced interval available
Applies to: 2010 · United States
Published interval: 10,000 mi / 16,000 km / 12 months · Whichever comes first.
Source: Mercedes-Benz USA — 2010 Maintenance Booklet · pages 12–63 — required at every annual/10,000-mile service · checked 2026-08-05
Brake fluid
Sourced interval available
Applies to: 2010 · United States
Published interval: 20,000 mi / 32,000 km / 24 months · Whichever comes first.
Source: Mercedes-Benz USA — 2010 Maintenance Booklet · page 16 and subsequent even-year services — replace brake fluid · checked 2026-08-05
Combination or dust filter
Sourced interval available
Applies to: 2010 · United States
Published interval: 20,000 mi / 32,000 km / 24 months · Whichever comes first.
Source: Mercedes-Benz USA — 2010 Maintenance Booklet · page 16 and subsequent even-year services — combination/dust-filter row · checked 2026-08-05
Spark plugs
Sourced interval available
Applies to: 2010 · Gasoline engines · United States
Published interval: 60,000 mi / 96,000 km / 72 months · Whichever comes first; excludes diesel engine 642.
Source: Mercedes-Benz USA — 2010 Maintenance Booklet · page 35 — 60,000-mile/6-year spark-plug row · checked 2026-08-05
Engine air filter
Exact reference available
Applies to: 2010 · United States
Published interval: 120,000 mi / 192,000 km / 144 months · Whichever comes first.
Source: Mercedes-Benz USA — 2010 Maintenance Booklet · page 61 — 120,000-mile/12-year air-filter row · checked 2026-08-05
M275 V12
Applies to: 2010 · M275 V12 · United States
Published interval: 60,000 mi / 96,000 km / 72 months · Whichever comes first.
Source: Mercedes-Benz USA — 2010 Maintenance Booklet · page 35 — engine 275 air-filter row · checked 2026-08-05
S 400 HYBRID — 3.5-liter V6 with electric motor
K&N 33-2181
Applies to: 2010 · 3.5-liter V6 with electric motor · S 400 HYBRID · Exact 2010 S 400 HYBRID engine application. Confirm VIN and build date before ordering.
Source: K&N Engineering — 2017 European Automotive Catalog, S-Class application tables (archived copy) · W221 S-Class table — S 400 HYBRID, 2010 — 33-2181 (two required) · checked 2026-09-01
Verified ordering references
- Service replacementK&N 33-2181
  Qty. 2 · Reusable engine air-filter element · catalog-listed
  K&N lists two elements for this application; confirm VIN and build date before ordering.
  Catalog: K&N Engineering — 2017 European Automotive Catalog, S-Class application tables (archived copy) · W221 S-Class table — S 400 HYBRID, 2010 — 33-2181 (two required) · checked 2026-09-01
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S 550 — 5.5-liter V8
K&N 33-2181
Applies to: 2010 · 5.5-liter V8 · S 550 · Exact 2010 S 550 engine application. Confirm VIN and build date before ordering.
Source: K&N Engineering — 2017 European Automotive Catalog, S-Class application tables (archived copy) · W221 S-Class table — S 550, 2010 — 33-2181 (two required) · checked 2026-09-01
Verified ordering references
- Service replacementK&N 33-2181
  Qty. 2 · Reusable engine air-filter element · catalog-listed
  K&N lists two elements for this application; confirm VIN and build date before ordering.
  Catalog: K&N Engineering — 2017 European Automotive Catalog, S-Class application tables (archived copy) · W221 S-Class table — S 550, 2010 — 33-2181 (two required) · checked 2026-09-01
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S 550 4MATIC — 5.5-liter V8
K&N 33-2181
Applies to: 2010 · 5.5-liter V8 · S 550 4MATIC · Exact 2010 S 550 4MATIC engine application. Confirm VIN and build date before ordering.
Source: K&N Engineering — 2017 European Automotive Catalog, S-Class application tables (archived copy) · W221 S-Class table — S 550 4MATIC, 2010 — 33-2181 (two required) · checked 2026-09-01
Verified ordering references
- Service replacementK&N 33-2181
  Qty. 2 · Reusable engine air-filter element · catalog-listed
  K&N lists two elements for this application; confirm VIN and build date before ordering.
  Catalog: K&N Engineering — 2017 European Automotive Catalog, S-Class application tables (archived copy) · W221 S-Class table — S 550 4MATIC, 2010 — 33-2181 (two required) · checked 2026-09-01
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S 600 — 5.5-liter twin-turbo V12
K&N 33-2412
Applies to: 2010 · 5.5-liter twin-turbo V12 · S 600 · Exact 2010 S 600 engine application. Confirm VIN and build date before ordering.
Source: K&N Engineering — 2017 European Automotive Catalog, S-Class application tables (archived copy) · W221 S-Class table — S 600, 2010 — 33-2412 · checked 2026-09-01
Verified ordering references
- Service replacementK&N 33-2412
  Qty. 1 · Reusable engine air-filter element · catalog-listed
  K&N lists one element for this application; confirm VIN and build date before ordering.
  Catalog: K&N Engineering — 2017 European Automotive Catalog, S-Class application tables (archived copy) · W221 S-Class table — S 600, 2010 — 33-2412 · checked 2026-09-01
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S 63 AMG — 6.2-liter AMG V8
K&N 33-2405
Applies to: 2010 · 6.2-liter AMG V8 · S 63 AMG · Exact 2010 S 63 AMG engine application. Confirm VIN and build date before ordering.
Source: K&N Engineering — 2017 European Automotive Catalog, S-Class application tables (archived copy) · W221 S-Class table — S 63 AMG 6.3i, 2010 — 33-2405 (two required) · checked 2026-09-01
Verified ordering references
- Service replacementK&N 33-2405
  Qty. 2 · Reusable engine air-filter element · catalog-listed
  K&N lists two elements for this application; confirm VIN and build date before ordering.
  Catalog: K&N Engineering — 2017 European Automotive Catalog, S-Class application tables (archived copy) · W221 S-Class table — S 63 AMG 6.3i, 2010 — 33-2405 (two required) · checked 2026-09-01
  Search this part on Amazon
S 65 AMG — 6.0-liter twin-turbo AMG V12
K&N 33-2412
Applies to: 2010 · 6.0-liter twin-turbo AMG V12 · S 65 AMG · Exact 2010 S 65 AMG engine application. Confirm VIN and build date before ordering.
Source: K&N Engineering — 2017 European Automotive Catalog, S-Class application tables (archived copy) · W221 S-Class table — S 65 AMG, 2010 — 33-2412 · checked 2026-09-01
Verified ordering references
- Service replacementK&N 33-2412
  Qty. 1 · Reusable engine air-filter element · catalog-listed
  K&N lists one element for this application; confirm VIN and build date before ordering.
  Catalog: K&N Engineering — 2017 European Automotive Catalog, S-Class application tables (archived copy) · W221 S-Class table — S 65 AMG, 2010 — 33-2412 · checked 2026-09-01
  Search this part on Amazon

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2010Mercedes-Benz S-Class

What do you need to know?

Find your exact 2010 S-Class

Mercedes-Benz S 400 HYBRID Automatic

Mercedes-Benz S 550 Automatic

Mercedes-Benz S 550 4MATIC Automatic

Mercedes-Benz S 600 Automatic

Mercedes-Benz S 63 AMG Automatic

Mercedes-Benz S 65 AMG Automatic

Overview

Specifications

What changed

Notable

Reliability & ownership notes

Keep your 2010 S-Class on the road

What this car needs & when

Bring this model year home

Sources