Fourth generation · W220 · 2000–2006
2001Mercedes-Benz S-Class
A lighter, sleeker S-Class with Airmatic air suspension, Distronic radar cruise, and the Pre-Safe pre-collision system (2002). Topped by the bi-turbo V12 S 600 and AMG S 65. US model years 2000–2006.
Photo: “2001 Mercedes-Benz S 430 (W 220) sedan (2010-09-23) 01” by OSX / Wikimedia Commons — Public domain. Cropped to 16:9.
Start here
What do you need to know?
This page covers the whole 2001 Mercedes-Benz S-Class model year. Choose your task first; exact trims and engines are separated where the factory offered different versions.
Complete, source-verified lineup
Find your exact 2001 S-Class
Start with a family, body style, or engine. Every card opens the facts and maintenance information for that factory version.
Verified complete for the U.S.-marketHow this lineup was verified
We checked this U.S.-market lineup against period sources for factory sedan, coupe, cabriolet, drivetrain, and powertrain roster represented by the cited exact-year or factory-archive evidence. Every version shown below has its own detail page.
Verified 2026-09-01 from Mercedes-Benz USA — 2001 S-Class operator's manual model roster.
Mercedes-Benz S 430 Automatic
- Body
- Four-door rear-wheel drive luxury sedan
- Engine
- 4.3-liter M113 V8
- Gearbox
- 5-speed automatic
- Built
- Regular production
Mercedes-Benz S 500 Automatic
- Body
- Four-door rear-wheel drive luxury sedan
- Engine
- 5.0-liter M113 V8
- Gearbox
- 5-speed automatic
- Built
- Regular production
Mercedes-Benz S 55 AMG Automatic
- Body
- Four-door rear-wheel drive luxury sedan
- Engine
- 5.4-liter AMG V8
- Gearbox
- 5-speed automatic
- Built
- Regular production
Mercedes-Benz S 600 Automatic
- Body
- Four-door rear-wheel drive luxury sedan
- Engine
- 5.8-liter M137 V12
- Gearbox
- 5-speed automatic
- Built
- Regular production
No factory configuration matches those filters.
The 2001 model year
Overview
For 2001, Mercedes-Benz USA's operator's manual identifies four W220 sedans: S 430, S 500, S 55 AMG, and S 600. The naturally aspirated AMG V8 and naturally aspirated V12 pages are kept separate from the later supercharged and twin-turbo versions because their service parts and performance hardware are not interchangeable.
Specifications
- Engines
- 4.3-liter M113 V8
- 5.0-liter M113 V8
- 5.4-liter AMG V8
- 5.8-liter M137 V12
- Transmissions
- 5-speed automatic
- Body styles
- Four-door rear-wheel drive luxury sedan
Year over year
What changed
- The S 55 AMG and S 600 expanded the U.S. range above the S 430 and S 500.
- All four cataloged configurations remained rear-wheel drive with five-speed automatics.
Worth knowing
Notable
- The 2001 manual is the exact model-year source; later facelift engine specifications are not backdated onto these cars.
Living with it
Reliability & ownership notes
- Inspect the individual car's Airmatic or optional Active Body Control system, electronics, corrosion condition, and documented service history; generation reputation is not proof of a fault on every car.
- Match filters, ignition parts, fluids, transmission service parts, and suspension components to the exact engine, drivetrain, chassis number, and build date before ordering.
Maintenance & service parts
Keep your 2001 S-Class on the road
Start with the service interval, then match the engine or exact version you own. Order links appear only when a catalog-backed part number is available, and every listing still needs a fitment check.
Service desk
What this car needs & when
Use this as a service-planning checklist for 2001 Mercedes-Benz S-Class. Start with the interval, confirm which engine or configuration you have, then use an exact ordering reference when one is verified.
- Service topics
- 7
- Factory intervals
- 7
- Fitment-scoped
- 7
- Exact references
- 1
Before orderingIdentify your engine, options and build date.Part numbers and sizes can change within one model year. Shopping links appear only for catalog-backed references; still verify the listing against your vehicle before ordering.
Engine oil and filter
Sourced interval available
Source: Mercedes-Benz — 2001 S 500 (W220/M113) FSS schedule, preserved by Operation CHARM · Service A and B schedules; FSS description — oil/filter at both services and 10,000-mile/365-day reset reference · checked
Dust filter
Sourced interval available
Source: Mercedes-Benz — 2001 S 500 (W220/M113) FSS schedule, preserved by Operation CHARM · Service A and B schedules — replace dust filter · checked
Brake fluid
Sourced interval available
Source: Mercedes-Benz — 2001 S 500 (W220/M113) FSS schedule, preserved by Operation CHARM · Supplemental Service Items — Every 2 Years · checked
Engine air-filter element
Exact reference available
Source: Mercedes-Benz — 2001 S 500 (W220/M113) FSS schedule, preserved by Operation CHARM · Supplemental Service Items — Every 60,000 miles or 4 Years · checked
S 430 — 4.3-liter M113 V8
K&N 33-2181
Source: K&N Engineering — 2017 European Automotive Catalog, S-Class application tables (archived copy) · W220 S-Class table — S 430, 2001 — 33-2181 (two required) · checked
Verified ordering references
- Service replacementK&N 33-2181
Qty. 2 · Reusable engine air-filter element · catalog-listed
K&N lists two elements for this application; confirm VIN and build date before ordering.
Catalog: K&N Engineering — 2017 European Automotive Catalog, S-Class application tables (archived copy) · W220 S-Class table — S 430, 2001 — 33-2181 (two required) · checked
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S 500 — 5.0-liter M113 V8
K&N 33-2181
Source: K&N Engineering — 2017 European Automotive Catalog, S-Class application tables (archived copy) · W220 S-Class table — S 500, 2001 — 33-2181 (two required) · checked
Verified ordering references
- Service replacementK&N 33-2181
Qty. 2 · Reusable engine air-filter element · catalog-listed
K&N lists two elements for this application; confirm VIN and build date before ordering.
Catalog: K&N Engineering — 2017 European Automotive Catalog, S-Class application tables (archived copy) · W220 S-Class table — S 500, 2001 — 33-2181 (two required) · checked
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S 55 AMG — 5.4-liter AMG V8
K&N 33-2181
Source: K&N Engineering — 2017 European Automotive Catalog, S-Class application tables (archived copy) · W220 S-Class table — S 55 AMG, 2001 — 33-2181 (two required) · checked
Verified ordering references
- Service replacementK&N 33-2181
Qty. 2 · Reusable engine air-filter element · catalog-listed
K&N lists two elements for this application; confirm VIN and build date before ordering.
Catalog: K&N Engineering — 2017 European Automotive Catalog, S-Class application tables (archived copy) · W220 S-Class table — S 55 AMG, 2001 — 33-2181 (two required) · checked
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S 600 — 5.8-liter M137 V12
K&N 33-2217
Source: K&N Engineering — 2017 European Automotive Catalog, S-Class application tables (archived copy) · W220 S-Class table — S 600, 2001 through 09/2002 — 33-2217 (two required) · checked
Verified ordering references
- Service replacementK&N 33-2217
Qty. 2 · Reusable engine air-filter element · catalog-listed
K&N lists two elements for this application; confirm VIN and build date before ordering.
Catalog: K&N Engineering — 2017 European Automotive Catalog, S-Class application tables (archived copy) · W220 S-Class table — S 600, 2001 through 09/2002 — 33-2217 (two required) · checked
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Fuel filter
Sourced interval available
Source: Mercedes-Benz — 2001 S 500 (W220/M113) FSS schedule, preserved by Operation CHARM · Supplemental Service Items — Every 60,000 miles or 5 Years · checked
Spark plugs
Sourced interval available
Source: Mercedes-Benz — 2001 S 500 (W220/M113) FSS schedule, preserved by Operation CHARM · Supplemental Service Items — Every 100,000 miles or 5 Years · checked
Recirculated-air and activated-charcoal prefilters
Sourced interval available
Source: Mercedes-Benz — 2001 S 500 (W220/M113) FSS schedule, preserved by Operation CHARM · Supplemental Service Items — Every 45,000 Miles or 2 Years · checked
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