Four-door 4MATIC all-wheel drive luxury sedan · 4.0-liter twin-turbo V8 mild hybrid
2021 Mercedes-Benz S 580 4MATIC Automatic
Mercedes-Benz's factory model archive identifies this 2021 S 580 4MATIC sedan with 4MATIC all-wheel drive; it is separated where drivetrain changes fitment.

Photo: “Mercedes-Benz S-Klasse (W223) S 580 e (2021) (53323040439)” by Charles from Port Chester, New York / Wikimedia Commons, licensed under CC BY 2.0. Cropped to 16:9.
Factory configuration
What this model is
- Trim
- S 580 4MATIC
- Body style
- Four-door 4MATIC all-wheel drive luxury sedan
- Engine
- 4.0-liter twin-turbo V8 mild hybrid
- Transmission
- 9-speed automatic
Configuration-specific ownership
Maintenance for this exact configuration
These items are filtered to the engine, transmission, trim, and model-year applicability recorded for this configuration. Broad Amazon category searches are suppressed here; shopping links appear only beside catalog-backed part numbers.
Service desk
What this car needs & when
Use this as a service-planning checklist for 2021 Mercedes-Benz S 580 4MATIC Automatic. Start with the interval, confirm which engine or configuration you have, then use an exact ordering reference when one is verified.
- Service topics
- 4
- Factory intervals
- 4
- Fitment-scoped
- 4
- Exact references
- 1
Before orderingIdentify your engine, options and build date.Part numbers and sizes can change within one model year. Shopping links appear only for catalog-backed references; still verify the listing against your vehicle before ordering.
Activated-charcoal combination and dust filters
Sourced interval available
Source: Mercedes-Benz USA service-and-warranty library — select 2021 S-Class · PDF page 5 — All Models: activated-charcoal combination filter and dust-filter rows · checked
Brake fluid
Sourced interval available
Source: Mercedes-Benz USA service-and-warranty library — select 2021 S-Class · PDF page 5 — All Models: brake-fluid change at 20,000-mile/two-year increments · checked
Engine air filter
Exact reference available
Source: Mercedes-Benz USA service-and-warranty library — select 2021 S-Class · PDF page 5 — All Models: engine air-filter replacement at 50,000 miles/5 years and 100,000 miles/10 years · checked
S 580 4MATIC — 4.0-liter twin-turbo V8 mild hybrid
K&N 33-3183
Source: K&N Engineering — Mercedes-Benz S-Class replacement-air-filter application catalog · 2021 Mercedes-Benz S580 4.0L V8 Gas — 33-3183 (two per package) · checked
Verified ordering references
- Service replacementK&N 33-3183
Qty. 2 · Reusable engine air-filter element · catalog-listed
K&N lists two elements for this application; confirm VIN and build date before ordering.
Catalog: K&N Engineering — Mercedes-Benz S-Class replacement-air-filter application catalog · 2021 Mercedes-Benz S580 4.0L V8 Gas — 33-3183 (two per package) · checked
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Automatic-transmission oil and filter
Sourced interval available
Source: Mercedes-Benz USA service-and-warranty library — select 2021 S-Class · PDF page 5 — All Models: transmission oil and filter at 60,000 miles/6 years · checked
Sources
Other 2021 configurations