Four-door rear-wheel-drive performance sedan · Handcrafted 6.0-liter biturbo AMG V12 (621 hp)
2016 Mercedes-Benz S-Class Mercedes-AMG S 65 Sedan
Mercedes-Benz USA's 2016 factory material identifies the Mercedes-AMG S 65 Sedan as a distinct U.S. configuration.

Photo: “2016 Mercedes-Benz S 350 d (W 222) sedan (2016-03-05) 03” by EurovisionNim / Wikimedia Commons, licensed under CC BY-SA 4.0. Cropped to 16:9.
Factory configuration
What this model is
- Trim
- AMG S 65
- Body style
- Four-door rear-wheel-drive performance sedan
- Engine
- Handcrafted 6.0-liter biturbo AMG V12 (621 hp)
- Transmission
- AMG SPEEDSHIFT PLUS 7G-TRONIC 7-speed
Compare related 2016 configurations
Compare up to twelve documented pairings, prioritizing the same engine, body, trim and gearbox as this car. This related selection is not a complete factory lineup.
Browse all documented 2016 configurations →
Compare 10 related configurations — current car marked
| Configuration | Engine | Transmission | Body |
|---|---|---|---|
| Mercedes-Benz S 550 Sedan | 4.7-liter biturbo V8 (449 hp) | 7-speed automatic | Four-door rear-wheel-drive sedan |
| Mercedes-Benz S 550 4MATIC Sedan | 4.7-liter biturbo V8 (449 hp) | 7-speed automatic | Four-door all-wheel-drive sedan |
| Mercedes-Benz S 550e Sedan | 3.0-liter biturbo V6 plug-in hybrid (436 hp combined) | 7G-TRONIC 7-speed automatic | Four-door rear-wheel-drive plug-in-hybrid sedan |
| Mercedes-Benz S 600 Sedan | 6.0-liter biturbo V12 (523 hp) | 7G-TRONIC 7-speed automatic | Four-door rear-wheel-drive sedan |
| Mercedes-AMG S 63 Sedan | Handcrafted 5.5-liter biturbo AMG V8 (577 hp) | AMG SPEEDSHIFT MCT 7-speed | Four-door performance all-wheel-drive sedan |
| Current carMercedes-AMG S 65 Sedan | Handcrafted 6.0-liter biturbo AMG V12 (621 hp) | AMG SPEEDSHIFT PLUS 7G-TRONIC 7-speed | Four-door rear-wheel-drive performance sedan |
| Mercedes-Maybach S 600 | 6.0-liter biturbo V12 (523 hp) | 7G-TRONIC 7-speed automatic | Four-door long-wheelbase rear-wheel-drive sedan |
| Mercedes-Benz S 550 4MATIC Coupe | 4.7-liter biturbo V8 (449 hp) | 7-speed automatic | Two-door all-wheel-drive coupe |
| Mercedes-AMG S 63 Coupe | Handcrafted 5.5-liter biturbo AMG V8 (577 hp) | AMG SPEEDSHIFT MCT 7-speed | Two-door performance all-wheel-drive coupe |
| Mercedes-AMG S 65 Coupe | Handcrafted 6.0-liter biturbo AMG V12 (621 hp) | AMG SPEEDSHIFT PLUS 7G-TRONIC 7-speed | Two-door rear-wheel-drive performance coupe |
Configuration-specific ownership
Maintenance for this exact configuration
These items are filtered to the engine, transmission, trim, and model-year applicability recorded for this configuration. Broad Amazon category searches are suppressed here; shopping links appear only beside catalog-backed part numbers.
Service desk
What this car needs & when
Use this as a service-planning checklist for 2016 Mercedes-Benz S-Class Mercedes-AMG S 65 Sedan. Start with the interval, confirm which engine or configuration you have, then use an exact ordering reference when one is verified.
- Service topics
- 2
- Scheduled topics
- 1
- Applicability stated
- 2
- Exact references
- 1
Before ordering Identify your engine, options and build date. Part numbers and sizes can change within one model year. Shopping links appear only for catalog-backed references; still verify the listing against your vehicle before ordering.
Brake fluidView intervals, applicability and sources
Brake fluid
Sourced interval available
Source: Mercedes-Benz USA — 2016 Maintenance Booklet · page 17 — additional maintenance work · checked
Engine air filterView intervals, applicability and sources
Engine air filter
Exact reference available
AMG S 65 — Handcrafted 6.0-liter biturbo AMG V12 (621 hp)
K&N 33-2412
Source: K&N Engineering — 2017 European Automotive Catalog, S-Class application tables (archived copy) · W222/Maybach S-Class table — AMG S 65, 2016 — 33-2412 · checked
Verified ordering references
- Service replacementK&N 33-2412
Qty. 1 · Reusable engine air-filter element · catalog-listed
K&N lists one element for this application; confirm VIN and build date before ordering.
Catalog: K&N Engineering — 2017 European Automotive Catalog, S-Class application tables (archived copy) · W222/Maybach S-Class table — AMG S 65, 2016 — 33-2412 · checked
Search this part on Amazon
AMG S 65 — Handcrafted 6.0-liter biturbo AMG V12 (621 hp)
K&N 33-2412
Source: K&N Engineering — 2017 European Automotive Catalog, S-Class application tables (archived copy) · W222/Maybach S-Class table — AMG S 65, 2016 — 33-2412 · checked
Verified ordering references
- Service replacementK&N 33-2412
Qty. 1 · Reusable engine air-filter element · catalog-listed
K&N lists one element for this application; confirm VIN and build date before ordering.
Catalog: K&N Engineering — 2017 European Automotive Catalog, S-Class application tables (archived copy) · W222/Maybach S-Class table — AMG S 65, 2016 — 33-2412 · checked
Search this part on Amazon
Search results may cover different scales, trims and model years. Check each listing; this search does not establish an exact replica of the documented vehicle.
Sources
Other 2016 configurations