Four-door rear-wheel-drive performance sedan · Handcrafted 6.0-liter biturbo AMG V12 (621 hp / 738 lb-ft)
2012 Mercedes-Benz S 65 AMG Sedan
The S 65 AMG is the separate 621-hp V12 flagship documented in the 2012 factory brochure.

Photo: “Mercedes-Benz S-Class S350 2012” by Captainmorlypogi1959 / Wikimedia Commons, licensed under CC BY-SA 4.0. Cropped to 16:9.
Factory configuration
What this model is
- Trim
- S 65 AMG
- Body style
- Four-door rear-wheel-drive performance sedan
- Engine
- Handcrafted 6.0-liter biturbo AMG V12 (621 hp / 738 lb-ft)
- Transmission
- Reinforced 5-speed AMG SPEEDSHIFT automatic
Configuration-specific ownership
Maintenance for this exact configuration
These items are filtered to the engine, transmission, trim, and model-year applicability recorded for this configuration. Broad Amazon category searches are suppressed here; shopping links appear only beside catalog-backed part numbers.
Service desk
What this car needs & when
Use this as a service-planning checklist for 2012 Mercedes-Benz S 65 AMG Sedan. Start with the interval, confirm which engine or configuration you have, then use an exact ordering reference when one is verified.
- Service topics
- 3
- Factory intervals
- 2
- Fitment-scoped
- 3
- Exact references
- 1
Before orderingIdentify your engine, options and build date.Part numbers and sizes can change within one model year. Shopping links appear only for catalog-backed references; still verify the listing against your vehicle before ordering.
Brake fluid
Sourced interval available
Source: Mercedes-Benz USA — 2012 Maintenance Booklet · required service work — brake-fluid replacement at each 20,000-mile/2-year service · checked
Combination and/or dust filter
Sourced interval available
Source: Mercedes-Benz USA — 2012 Maintenance Booklet · required service work — combination/dust-filter replacement at each 20,000-mile/2-year service · checked
Engine air filter
Exact reference available
The part reference below is catalog fitment only; retain the separately sourced factory service interval where one is shown.
S 65 AMG — Handcrafted 6.0-liter biturbo AMG V12 (621 hp / 738 lb-ft)
K&N 33-2412
Source: K&N Engineering — 2017 European Automotive Catalog, S-Class application tables (archived copy) · W221 S-Class table — S 65 AMG, 2012 — 33-2412 · checked
Verified ordering references
- Service replacementK&N 33-2412
Qty. 1 · Reusable engine air-filter element · catalog-listed
K&N lists one element for this application; confirm VIN and build date before ordering.
Catalog: K&N Engineering — 2017 European Automotive Catalog, S-Class application tables (archived copy) · W221 S-Class table — S 65 AMG, 2012 — 33-2412 · checked
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Sources
Other 2012 configurations